One possible reason for chest pain is psoriatic arthritis (PsA), inflammatory arthritis that affects some people with psoriasis — a condition that causes an abnormal buildup of skin cells.

The Problem Could Be Musculoskeletal

For people with psoriatic arthritis, “perhaps the most common type of chest pain is costochondritis," says Adam Kreitenberg, MD, a rheumatologist in Los Angeles. Costochondritis is inflammation of the cartilage connecting the ribs to the breastbone (sternum). “This chest or rib pain can be quite severe and cause pain with deep breathing, physical activity, and even coughing or sneezing,” Dr. Kreitenberg says. You might think you’re having a heart attack. Doctors typically diagnose costochondritis with a physical exam, feeling (palpating) the areas where the ribs attach to the sternum. “While X-rays and bloodwork are often not necessary, they can be helpful in ruling out other and potentially more severe diagnoses, such as heart attack,” says Kreitenberg. RELATED: Psoriatic Arthritis: 11 Tips for Your Next Doctor’s Visit

What’s the Best Treatment?

Treatment for chest and rib pain caused by costochondritis may include therapy for the underlying psoriatic arthritis, such as disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include ibuprofen (Advil), naproxen (Aleve), and diclofenac (Voltaren). “It may also include biologics. Ask your doctor about the right medicine for you, and get an accurate diagnosis,” says Rajat Bhatt, MD, a rheumatologist in Richmond, Texas. RELATED: Expert Tips on Diagnosing and Treating Psoriatic Arthritis

Heart Disease May Be the Cause

If you have psoriatic arthritis and experience chest or rib pain, the problem could in fact be heart disease. A study published in May 2021 in the Journal of Internal Medicine found that “both psoriasis and PsA were associated with an increased prevalence of coronary calcification. Psoriasis patients also showed an increased prevalence of severe calcification.” “Patients with chronic autoimmune inflammatory conditions may have high levels of circulating inflammation throughout their bodies, which places them at increased risk of cardiovascular disease,” Kreitenberg explains. “Therefore the classic chest pain associated with a heart attack should be closely monitored.” Dr. Bhatt points out that cardiac complications can sometimes come from certain PsA medications. “Some of these medications can cause thromboembolism and pulmonary embolism (blood clots in the lungs). JAK inhibitors, for example, can cause the latter,” he says. Pay particular attention if you also experience breathlessness, pain or numbness in your legs or arms, or cough, fever, or swelling in the legs.

Heart Disease Treatment

If the cause of the pain does turn out to be heart disease, get seen by a doctor in person and go to the ER. You may need to be admitted to the hospital for further management. If you aren’t already doing so, you might need to start taking aspirin, begin cholesterol lowering therapy, and make dietary changes and other interventions, says Bhatt.

Look for These Other Symptoms

If you are experiencing chest and rib pain as a PsA patient, Bhatt advises you to watch out for these other symptoms, which could indicate something more than heartburn is happening.

Skin rashSwollen jointsWeak and pitted nails. In some cases, the nails actually peel off.Low back painFloaters or painful redness in the eyesDiarrhea or constipationGastroesophageal reflux

Other Possible Causes

Chest pain in people with PsA can also be caused by:

Another organ system being affected by PsAChronic pain syndromeSide effect of non-aspirin NSAIDs, which can increase the risk of heart attack, as the U.S. Food and Drug Administration (FDA) notes

No matter the cause, it’s important to get any chest pain checked out. As Bhatt says, “Chest pain should not be taken lightly. Err on the side of caution and contact your doctor as soon as possible to distinguish the various causes.”